Treatments
October 2025
Polynucleotides explained: why regenerative injectables are gaining attention
A clear look at what polynucleotides are, how they work, and why they have become a topic of interest in UK aesthetics.
A clear look at what polynucleotides are, how they work, and why they have become a topic of interest in UK aesthetics.
Over the past year or two, polynucleotides have become one of the most discussed treatments in the UK aesthetics industry. For those unfamiliar with the term, this can feel confusing. What exactly are polynucleotides, how do they differ from other injectable treatments, and why are practitioners and patients talking about them more?
This article aims to explain polynucleotides in straightforward terms, without exaggeration or promotional language. Understanding what a treatment does and how it works is an important part of making informed decisions about your skin.
Polynucleotides are chains of nucleotides, which are the building blocks of DNA. In aesthetic treatments, polynucleotides are typically derived from salmon or trout DNA, which has been purified and processed for safe use in humans.
When injected into the skin, polynucleotides are thought to support the skin's natural repair and regeneration processes. Rather than adding volume or paralysing muscles like fillers or anti-wrinkle injections, polynucleotides work at a cellular level to improve skin quality over time.
This makes them part of a broader category sometimes called regenerative aesthetics, which focuses on supporting the skin's own biology rather than masking or replacing its function.
The proposed mechanism of polynucleotides involves several processes. They are thought to stimulate fibroblast activity, which are the cells responsible for producing collagen and elastin. They may also have antioxidant and anti-inflammatory properties, helping to protect cells from damage and support healing.
Additionally, polynucleotides are believed to improve hydration at a cellular level, which can contribute to better skin texture and a healthier appearance over time.
It is worth noting that while there is growing evidence supporting these effects, research in this area is still developing. As with many aesthetic treatments, individual results can vary.
There are several reasons why polynucleotides have become a topic of conversation in UK aesthetics. One is the broader shift towards treatments that support skin health rather than simply correcting specific concerns. Many patients are looking for ways to improve their overall skin quality, and polynucleotides fit within this approach.
Another factor is their suitability for areas that can be difficult to treat with other injectables. The under-eye area, for example, is often too delicate for traditional fillers, but polynucleotides may be used here to improve skin quality without adding volume.
There is also growing interest in treatments that work well alongside hormone changes. Women experiencing perimenopause or menopause often notice significant changes to their skin quality, and regenerative treatments like polynucleotides may help support the skin during this transition.
It can be helpful to understand how polynucleotides fit within the broader landscape of aesthetic treatments.
Unlike hyaluronic acid fillers, polynucleotides do not add volume. They will not plump lips or define cheekbones. Instead, they work to improve the quality and resilience of the skin itself.
Unlike anti-wrinkle injections, polynucleotides do not affect muscle movement. They will not smooth dynamic wrinkles caused by facial expressions.
They are perhaps most similar to other skin quality treatments like Profhilo or skin boosters, in that they aim to improve hydration, texture and overall skin health. However, their mechanism of action is different, focusing on cellular regeneration rather than primarily hydration.
For many patients, polynucleotides work best as part of a broader approach to skin health, potentially alongside other treatments depending on individual needs and goals.
Polynucleotide treatments are administered through small injections into the skin. The treatment area and technique will depend on the specific concerns being addressed. Common areas include the face, under-eyes, neck and hands.
A typical course involves two to three sessions spaced a few weeks apart, with maintenance treatments as needed. Results develop gradually as the skin responds to the treatment, with most people noticing improvements in skin quality over the weeks following their sessions.
As with any injectable treatment, there is some potential for side effects such as redness, swelling or bruising at injection sites. These are usually mild and resolve within a few days.
Polynucleotides may be worth considering for those who are primarily interested in improving skin quality rather than adding volume or reducing wrinkles caused by muscle movement. They can be particularly suitable for:
As with any aesthetic treatment, it is important to have realistic expectations about what polynucleotides can achieve. They are not a dramatic or instant solution, but rather a gradual support for skin health that works over time.
A thorough consultation with a qualified practitioner is essential before any treatment. This allows you to discuss your specific concerns, understand whether polynucleotides are appropriate for you, and ask any questions you may have.
The aesthetics industry can sometimes feel overwhelming, with new treatments and trends emerging regularly. Taking the time to understand what a treatment actually does, rather than relying on marketing claims, is always worthwhile.
If you have questions about polynucleotides or would like to discuss whether they might be suitable for your skin, I am happy to help.
Sarah